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The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance. / Gehre, Florian; Otu, Jacob; Kendall, Lindsay; Forson, Audrey; Kwara, Awewura; Kudzawu, Samuel; Kehinde, Aderemi O.; Adebiyi, Oludele; Salako, Kayode; Baldeh, Ignatius; Jallow, Aisha; Jallow, Mamadou; Dagnra, Anoumou; Disse, Kodjo; Kadanga, Essosimna A.; Idigbe, Emmanuel Oni; Onubogu, Catherine; Onyejepu, Nneka; Gaye-Diallo, Aissatou; Ba-Diallo, Awa; Rabna, Paulo; Mane, Morto; Sanogo, Moumine; Diarra, Bassirou; Dezemon, Zingue; Sanou, Adama; Senghore, Madikay; Kwambana-Adams, Brenda A.; Demba, Edward; Faal-Jawara, Tutty; Kumar, Samrat; Tientcheu, Leopold D.; Jallow, Adama; Ceesay, Samba; Adetifa, Ifedayo; Jaye, Assan; Pallen, Mark J.; D'Alessandro, Umberto; Kampmann, Beate; Adegbola, Richard A.; Mboup, Souleymane; Corrah, Tumani; de Jong, Bouke C.; Antonio, Martin.

In: BMC Medicine, Vol. 14, 160, 2016.

Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikel

Harvard

Gehre, F, Otu, J, Kendall, L, Forson, A, Kwara, A, Kudzawu, S, Kehinde, AO, Adebiyi, O, Salako, K, Baldeh, I, Jallow, A, Jallow, M, Dagnra, A, Disse, K, Kadanga, EA, Idigbe, EO, Onubogu, C, Onyejepu, N, Gaye-Diallo, A, Ba-Diallo, A, Rabna, P, Mane, M, Sanogo, M, Diarra, B, Dezemon, Z, Sanou, A, Senghore, M, Kwambana-Adams, BA, Demba, E, Faal-Jawara, T, Kumar, S, Tientcheu, LD, Jallow, A, Ceesay, S, Adetifa, I, Jaye, A, Pallen, MJ, D'Alessandro, U, Kampmann, B, Adegbola, RA, Mboup, S, Corrah, T, de Jong, BC & Antonio, M 2016, 'The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance', BMC Medicine, vol. 14, 160. https://doi.org/10.1186/s12916-016-0704-5

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Author

Gehre, Florian ; Otu, Jacob ; Kendall, Lindsay ; Forson, Audrey ; Kwara, Awewura ; Kudzawu, Samuel ; Kehinde, Aderemi O. ; Adebiyi, Oludele ; Salako, Kayode ; Baldeh, Ignatius ; Jallow, Aisha ; Jallow, Mamadou ; Dagnra, Anoumou ; Disse, Kodjo ; Kadanga, Essosimna A. ; Idigbe, Emmanuel Oni ; Onubogu, Catherine ; Onyejepu, Nneka ; Gaye-Diallo, Aissatou ; Ba-Diallo, Awa ; Rabna, Paulo ; Mane, Morto ; Sanogo, Moumine ; Diarra, Bassirou ; Dezemon, Zingue ; Sanou, Adama ; Senghore, Madikay ; Kwambana-Adams, Brenda A. ; Demba, Edward ; Faal-Jawara, Tutty ; Kumar, Samrat ; Tientcheu, Leopold D. ; Jallow, Adama ; Ceesay, Samba ; Adetifa, Ifedayo ; Jaye, Assan ; Pallen, Mark J. ; D'Alessandro, Umberto ; Kampmann, Beate ; Adegbola, Richard A. ; Mboup, Souleymane ; Corrah, Tumani ; de Jong, Bouke C. ; Antonio, Martin. / The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance. In: BMC Medicine. 2016 ; Vol. 14.

BibTeX

@article{d13b1ec79b664671ad591ccc7ee08703,
title = "The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance",
abstract = "Background: Drug-resistant tuberculosis (TB) is a global public health problem. Adequate management requires baseline drug-resistance prevalence data. In West Africa, due to a poor laboratory infrastructure and inadequate capacity, such data are scarce. Therefore, the true extent of drug-resistant TB was hitherto undetermined. In 2008, a new research network, the West African Network of Excellence for Tuberculosis, AIDS and Malaria (WANETAM), was founded, comprising nine study sites from eight West African countries (Burkina Faso, The Gambia, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal and Togo). The goal was to establish Good Clinical Laboratory Practice (GCLP) principles and build capacity in standardised smear microscopy and mycobacterial culture across partnering laboratories to generate the first comprehensive West African drug-resistance data.Methods: Following GCLP and laboratory training sessions, TB isolates were collected at sentinel referral sites between 2009-2013 and tested for first-and second-line drug resistance.Results: From the analysis of 974 isolates, an unexpectedly high prevalence of multi-drug-resistant (MDR) strains was found in new (6 {\%}) and retreatment patients (35 {\%}) across all sentinel sites, with the highest prevalence amongst retreatment patients in Bamako, Mali (59 {\%}) and the two Nigerian sites in Ibadan and Lagos (39 {\%} and 66 {\%}). In Lagos, MDR is already spreading actively amongst 32 {\%} of new patients. Pre-extensively drug-resistant (pre-XDR) isolates are present in all sites, with Ghana showing the highest proportion (35 {\%} of MDR). In Ghana and Togo, pre-XDR isolates are circulating amongst new patients.Conclusions: West African drug-resistance prevalence poses a previously underestimated, yet serious public health threat, and our estimates obtained differ significantly from previous World Health Organisation (WHO) estimates. Therefore, our data are reshaping current concepts and are essential in informing WHO and public health strategists to implement urgently needed surveillance and control interventions in West Africa.",
keywords = "Tuberculosis, Extensively drug-resistant tuberculosis, West Africa, Drug-resistance surveillance, Capacity building, MYCOBACTERIUM-TUBERCULOSIS, NIGERIA, PREVALENCE, TB",
author = "Florian Gehre and Jacob Otu and Lindsay Kendall and Audrey Forson and Awewura Kwara and Samuel Kudzawu and Kehinde, {Aderemi O.} and Oludele Adebiyi and Kayode Salako and Ignatius Baldeh and Aisha Jallow and Mamadou Jallow and Anoumou Dagnra and Kodjo Disse and Kadanga, {Essosimna A.} and Idigbe, {Emmanuel Oni} and Catherine Onubogu and Nneka Onyejepu and Aissatou Gaye-Diallo and Awa Ba-Diallo and Paulo Rabna and Morto Mane and Moumine Sanogo and Bassirou Diarra and Zingue Dezemon and Adama Sanou and Madikay Senghore and Kwambana-Adams, {Brenda A.} and Edward Demba and Tutty Faal-Jawara and Samrat Kumar and Tientcheu, {Leopold D.} and Adama Jallow and Samba Ceesay and Ifedayo Adetifa and Assan Jaye and Pallen, {Mark J.} and Umberto D'Alessandro and Beate Kampmann and Adegbola, {Richard A.} and Souleymane Mboup and Tumani Corrah and {de Jong}, {Bouke C.} and Martin Antonio",
note = "CPDF",
year = "2016",
doi = "10.1186/s12916-016-0704-5",
language = "English",
volume = "14",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BMC",

}

RIS

TY - JOUR

T1 - The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance

AU - Gehre, Florian

AU - Otu, Jacob

AU - Kendall, Lindsay

AU - Forson, Audrey

AU - Kwara, Awewura

AU - Kudzawu, Samuel

AU - Kehinde, Aderemi O.

AU - Adebiyi, Oludele

AU - Salako, Kayode

AU - Baldeh, Ignatius

AU - Jallow, Aisha

AU - Jallow, Mamadou

AU - Dagnra, Anoumou

AU - Disse, Kodjo

AU - Kadanga, Essosimna A.

AU - Idigbe, Emmanuel Oni

AU - Onubogu, Catherine

AU - Onyejepu, Nneka

AU - Gaye-Diallo, Aissatou

AU - Ba-Diallo, Awa

AU - Rabna, Paulo

AU - Mane, Morto

AU - Sanogo, Moumine

AU - Diarra, Bassirou

AU - Dezemon, Zingue

AU - Sanou, Adama

AU - Senghore, Madikay

AU - Kwambana-Adams, Brenda A.

AU - Demba, Edward

AU - Faal-Jawara, Tutty

AU - Kumar, Samrat

AU - Tientcheu, Leopold D.

AU - Jallow, Adama

AU - Ceesay, Samba

AU - Adetifa, Ifedayo

AU - Jaye, Assan

AU - Pallen, Mark J.

AU - D'Alessandro, Umberto

AU - Kampmann, Beate

AU - Adegbola, Richard A.

AU - Mboup, Souleymane

AU - Corrah, Tumani

AU - de Jong, Bouke C.

AU - Antonio, Martin

N1 - CPDF

PY - 2016

Y1 - 2016

N2 - Background: Drug-resistant tuberculosis (TB) is a global public health problem. Adequate management requires baseline drug-resistance prevalence data. In West Africa, due to a poor laboratory infrastructure and inadequate capacity, such data are scarce. Therefore, the true extent of drug-resistant TB was hitherto undetermined. In 2008, a new research network, the West African Network of Excellence for Tuberculosis, AIDS and Malaria (WANETAM), was founded, comprising nine study sites from eight West African countries (Burkina Faso, The Gambia, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal and Togo). The goal was to establish Good Clinical Laboratory Practice (GCLP) principles and build capacity in standardised smear microscopy and mycobacterial culture across partnering laboratories to generate the first comprehensive West African drug-resistance data.Methods: Following GCLP and laboratory training sessions, TB isolates were collected at sentinel referral sites between 2009-2013 and tested for first-and second-line drug resistance.Results: From the analysis of 974 isolates, an unexpectedly high prevalence of multi-drug-resistant (MDR) strains was found in new (6 %) and retreatment patients (35 %) across all sentinel sites, with the highest prevalence amongst retreatment patients in Bamako, Mali (59 %) and the two Nigerian sites in Ibadan and Lagos (39 % and 66 %). In Lagos, MDR is already spreading actively amongst 32 % of new patients. Pre-extensively drug-resistant (pre-XDR) isolates are present in all sites, with Ghana showing the highest proportion (35 % of MDR). In Ghana and Togo, pre-XDR isolates are circulating amongst new patients.Conclusions: West African drug-resistance prevalence poses a previously underestimated, yet serious public health threat, and our estimates obtained differ significantly from previous World Health Organisation (WHO) estimates. Therefore, our data are reshaping current concepts and are essential in informing WHO and public health strategists to implement urgently needed surveillance and control interventions in West Africa.

AB - Background: Drug-resistant tuberculosis (TB) is a global public health problem. Adequate management requires baseline drug-resistance prevalence data. In West Africa, due to a poor laboratory infrastructure and inadequate capacity, such data are scarce. Therefore, the true extent of drug-resistant TB was hitherto undetermined. In 2008, a new research network, the West African Network of Excellence for Tuberculosis, AIDS and Malaria (WANETAM), was founded, comprising nine study sites from eight West African countries (Burkina Faso, The Gambia, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal and Togo). The goal was to establish Good Clinical Laboratory Practice (GCLP) principles and build capacity in standardised smear microscopy and mycobacterial culture across partnering laboratories to generate the first comprehensive West African drug-resistance data.Methods: Following GCLP and laboratory training sessions, TB isolates were collected at sentinel referral sites between 2009-2013 and tested for first-and second-line drug resistance.Results: From the analysis of 974 isolates, an unexpectedly high prevalence of multi-drug-resistant (MDR) strains was found in new (6 %) and retreatment patients (35 %) across all sentinel sites, with the highest prevalence amongst retreatment patients in Bamako, Mali (59 %) and the two Nigerian sites in Ibadan and Lagos (39 % and 66 %). In Lagos, MDR is already spreading actively amongst 32 % of new patients. Pre-extensively drug-resistant (pre-XDR) isolates are present in all sites, with Ghana showing the highest proportion (35 % of MDR). In Ghana and Togo, pre-XDR isolates are circulating amongst new patients.Conclusions: West African drug-resistance prevalence poses a previously underestimated, yet serious public health threat, and our estimates obtained differ significantly from previous World Health Organisation (WHO) estimates. Therefore, our data are reshaping current concepts and are essential in informing WHO and public health strategists to implement urgently needed surveillance and control interventions in West Africa.

KW - Tuberculosis

KW - Extensively drug-resistant tuberculosis

KW - West Africa

KW - Drug-resistance surveillance

KW - Capacity building

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - NIGERIA

KW - PREVALENCE

KW - TB

U2 - 10.1186/s12916-016-0704-5

DO - 10.1186/s12916-016-0704-5

M3 - A1: Web of Science-article

VL - 14

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

M1 - 160

ER -

ID: 2668708