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Salmonella Typhi from blood cultures in the Democratic Republic of the Congo: a 10-year surveillance. / Tack, Bieke; Phoba, Marie-France; Van Puyvelde, Sandra; Kalonji, Lisette M; Hardy, Liselotte; Barbé, Barbara; Van der Sande, Marianne A B; Monsieurs, Elise; Deborggraeve, Stijn; Lunguya, Octavie; Jacobs, Jan.

In: Clinical Infectious Diseases, Vol. 68, Nr. Suppl 2, 2019, blz. S130-S137.

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Tack, Bieke ; Phoba, Marie-France ; Van Puyvelde, Sandra ; Kalonji, Lisette M ; Hardy, Liselotte ; Barbé, Barbara ; Van der Sande, Marianne A B ; Monsieurs, Elise ; Deborggraeve, Stijn ; Lunguya, Octavie ; Jacobs, Jan. / Salmonella Typhi from blood cultures in the Democratic Republic of the Congo: a 10-year surveillance. In: Clinical Infectious Diseases. 2019 ; Vol. 68, Nr. Suppl 2. blz. S130-S137.

BibTeX

@article{21a693c5a63e4db8bfe0d6eb92fdbda4,
title = "Salmonella Typhi from blood cultures in the Democratic Republic of the Congo: a 10-year surveillance",
abstract = "BACKGROUND: This study gives an overview of a decade (2007-2017) of hospital-based Salmonella Typhi bloodstream infection (BSI) surveillance in the Democratic Republic of the Congo (DRC), at 4 main sampling sites.METHODS: Blood cultures were sampled in hospital-admitted patients with suspected BSI, according to standardized clinical indications. The results of the surveillance period 2015-2017 were compiled with those of previous surveillance periods (2007-2010 and 2011-2014). Whole genome sequencing of isolates with decreased ciprofloxacin susceptibility (DCS) was performed.RESULTS: Salmonella Typhi was isolated in 1.4{\%} (531/37 388) and 10.3{\%} (531/5177) of suspected and culture-confirmed BSI episodes, respectively. Salmonella Typhi ranked first among the BSI pathogens in adults (n = 220), but was mostly (n = 301 [56.7{\%}]) isolated from children, of which 72.1{\%} (217/301) and 31.6{\%} (95/301) were <10 years and <5 years old, respectively. Multidrug resistance (MDR), DCS, and combined MDR/DCS were found in 38.3{\%} (n = 180), 24.5{\%} (n = 115), and 11.9{\%} (n = 56) of 470 first isolates, respectively. MDR and DCS rates had increased since 2007, but remained stable during 2015-2017 with no geographical clustering at the province level. Most (91/93 [97.8{\%}]) DCS isolates sequenced belonged to Genotyphi genotype 2.5.1, and gyr S83 was the most frequent DCS mutation (76/93 [81.7{\%}]). Infections occurred perennially, but increased during the rainy season.CONCLUSIONS: Salmonella Typhi was a frequent cause of BSI in adults and children in DRC, with high rates of antibiotic resistance. Sustainable surveillance and implementation of vaccination are compelling.",
author = "Bieke Tack and Marie-France Phoba and {Van Puyvelde}, Sandra and Kalonji, {Lisette M} and Liselotte Hardy and Barbara Barb{\'e} and {Van der Sande}, {Marianne A B} and Elise Monsieurs and Stijn Deborggraeve and Octavie Lunguya and Jan Jacobs",
note = "CPDF; {\circledC} The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2019",
doi = "10.1093/cid/ciy1116",
language = "English",
volume = "68",
pages = "S130--S137",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "OXFORD UNIV PRESS INC",
number = "Suppl 2",

}

RIS

TY - JOUR

T1 - Salmonella Typhi from blood cultures in the Democratic Republic of the Congo: a 10-year surveillance

AU - Tack, Bieke

AU - Phoba, Marie-France

AU - Van Puyvelde, Sandra

AU - Kalonji, Lisette M

AU - Hardy, Liselotte

AU - Barbé, Barbara

AU - Van der Sande, Marianne A B

AU - Monsieurs, Elise

AU - Deborggraeve, Stijn

AU - Lunguya, Octavie

AU - Jacobs, Jan

N1 - CPDF; © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: This study gives an overview of a decade (2007-2017) of hospital-based Salmonella Typhi bloodstream infection (BSI) surveillance in the Democratic Republic of the Congo (DRC), at 4 main sampling sites.METHODS: Blood cultures were sampled in hospital-admitted patients with suspected BSI, according to standardized clinical indications. The results of the surveillance period 2015-2017 were compiled with those of previous surveillance periods (2007-2010 and 2011-2014). Whole genome sequencing of isolates with decreased ciprofloxacin susceptibility (DCS) was performed.RESULTS: Salmonella Typhi was isolated in 1.4% (531/37 388) and 10.3% (531/5177) of suspected and culture-confirmed BSI episodes, respectively. Salmonella Typhi ranked first among the BSI pathogens in adults (n = 220), but was mostly (n = 301 [56.7%]) isolated from children, of which 72.1% (217/301) and 31.6% (95/301) were <10 years and <5 years old, respectively. Multidrug resistance (MDR), DCS, and combined MDR/DCS were found in 38.3% (n = 180), 24.5% (n = 115), and 11.9% (n = 56) of 470 first isolates, respectively. MDR and DCS rates had increased since 2007, but remained stable during 2015-2017 with no geographical clustering at the province level. Most (91/93 [97.8%]) DCS isolates sequenced belonged to Genotyphi genotype 2.5.1, and gyr S83 was the most frequent DCS mutation (76/93 [81.7%]). Infections occurred perennially, but increased during the rainy season.CONCLUSIONS: Salmonella Typhi was a frequent cause of BSI in adults and children in DRC, with high rates of antibiotic resistance. Sustainable surveillance and implementation of vaccination are compelling.

AB - BACKGROUND: This study gives an overview of a decade (2007-2017) of hospital-based Salmonella Typhi bloodstream infection (BSI) surveillance in the Democratic Republic of the Congo (DRC), at 4 main sampling sites.METHODS: Blood cultures were sampled in hospital-admitted patients with suspected BSI, according to standardized clinical indications. The results of the surveillance period 2015-2017 were compiled with those of previous surveillance periods (2007-2010 and 2011-2014). Whole genome sequencing of isolates with decreased ciprofloxacin susceptibility (DCS) was performed.RESULTS: Salmonella Typhi was isolated in 1.4% (531/37 388) and 10.3% (531/5177) of suspected and culture-confirmed BSI episodes, respectively. Salmonella Typhi ranked first among the BSI pathogens in adults (n = 220), but was mostly (n = 301 [56.7%]) isolated from children, of which 72.1% (217/301) and 31.6% (95/301) were <10 years and <5 years old, respectively. Multidrug resistance (MDR), DCS, and combined MDR/DCS were found in 38.3% (n = 180), 24.5% (n = 115), and 11.9% (n = 56) of 470 first isolates, respectively. MDR and DCS rates had increased since 2007, but remained stable during 2015-2017 with no geographical clustering at the province level. Most (91/93 [97.8%]) DCS isolates sequenced belonged to Genotyphi genotype 2.5.1, and gyr S83 was the most frequent DCS mutation (76/93 [81.7%]). Infections occurred perennially, but increased during the rainy season.CONCLUSIONS: Salmonella Typhi was a frequent cause of BSI in adults and children in DRC, with high rates of antibiotic resistance. Sustainable surveillance and implementation of vaccination are compelling.

U2 - 10.1093/cid/ciy1116

DO - 10.1093/cid/ciy1116

M3 - A1: Web of Science-article

C2 - 30845337

VL - 68

SP - S130-S137

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - Suppl 2

ER -

ID: 3000269