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Next-generation molecular surveillance of TriTryp diseases. / Domagalska, Malgorzata Anna; Dujardin, Jean-Claude.

In: Trends In Parasitology, Vol. 36, Nr. 4, 2020, blz. 356-367.

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@article{b9940c47fe994c749f569fe4e2ea8d3e,
title = "Next-generation molecular surveillance of TriTryp diseases",
abstract = "Elimination programs targeting TriTryp diseases (Leishmaniasis, Chagas' disease, human African trypanosomiasis) significantly reduced the number of cases. Continued surveillance is crucial to sustain this progress, but parasite molecular surveillance by genotyping is currently lacking. We explain here which epidemiological questions of public health and clinical relevance could be answered by means of molecular surveillance. Whole-genome sequencing (WGS) for molecular surveillance will be an important added value, where we advocate that preference should be given to direct sequencing of the parasite's genome in host tissues instead of analysis of cultivated isolates. The main challenges here, and recent technological advances, are discussed. We conclude with a series of recommendations for implementing whole-genome sequencing for molecular surveillance.",
author = "Domagalska, {Malgorzata Anna} and Jean-Claude Dujardin",
note = "CPDF; Copyright {\circledC} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
doi = "10.1016/j.pt.2020.01.008",
language = "English",
volume = "36",
pages = "356--367",
journal = "Trends In Parasitology",
issn = "1471-4922",
publisher = "ELSEVIER SCI LTD",
number = "4",

}

RIS

TY - JOUR

T1 - Next-generation molecular surveillance of TriTryp diseases

AU - Domagalska, Malgorzata Anna

AU - Dujardin, Jean-Claude

N1 - CPDF; Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020

Y1 - 2020

N2 - Elimination programs targeting TriTryp diseases (Leishmaniasis, Chagas' disease, human African trypanosomiasis) significantly reduced the number of cases. Continued surveillance is crucial to sustain this progress, but parasite molecular surveillance by genotyping is currently lacking. We explain here which epidemiological questions of public health and clinical relevance could be answered by means of molecular surveillance. Whole-genome sequencing (WGS) for molecular surveillance will be an important added value, where we advocate that preference should be given to direct sequencing of the parasite's genome in host tissues instead of analysis of cultivated isolates. The main challenges here, and recent technological advances, are discussed. We conclude with a series of recommendations for implementing whole-genome sequencing for molecular surveillance.

AB - Elimination programs targeting TriTryp diseases (Leishmaniasis, Chagas' disease, human African trypanosomiasis) significantly reduced the number of cases. Continued surveillance is crucial to sustain this progress, but parasite molecular surveillance by genotyping is currently lacking. We explain here which epidemiological questions of public health and clinical relevance could be answered by means of molecular surveillance. Whole-genome sequencing (WGS) for molecular surveillance will be an important added value, where we advocate that preference should be given to direct sequencing of the parasite's genome in host tissues instead of analysis of cultivated isolates. The main challenges here, and recent technological advances, are discussed. We conclude with a series of recommendations for implementing whole-genome sequencing for molecular surveillance.

U2 - 10.1016/j.pt.2020.01.008

DO - 10.1016/j.pt.2020.01.008

M3 - A1: Web of Science-article

VL - 36

SP - 356

EP - 367

JO - Trends In Parasitology

JF - Trends In Parasitology

SN - 1471-4922

IS - 4

ER -

ID: 3286363