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@article{3f67382f3c73415bbabf065c010baa6f,
title = "Multidrug-resistant patients receiving treatment in Niger who are infected with M. tuberculosis Cameroon family convert faster in smear and culture than those with M. tuberculosis Ghana family",
abstract = "In this study, we analyzed the M. tuberculosis complex (MTBc) population structure among multidrug-resistant TB (MDR-TB) patients in Niger and tested whether the Cameroon family displayed a slower response to MDR-TB treatment. We genotyped baseline clinical isolates that had been collected from pulmonary MDR-TB patients recruited consecutively between 2008 and 2016 in Niger. Spoligotyping was used to analyze the genetic diversity of mycobacterial lineages, and Kaplan Meier's analysis to compare treatment outcomes. A total of 222 MTBc isolates were genotyped; 204 (91,9{\%}) were identified as the Euro-American L4 lineage, with the Ghana family (106, 47,4{\%}) and the Cameroon family (63, 28,4{\%}) being predominant. Patients infected by Cameroon family isolates 61(96,8{\%}) showed faster conversion (log-rank p < 0.01) than those infected with Ghana family isolates (91,5{\%}), and were more likely to experience favorable outcome (adjusted odds ratio [aOR] 4.4; 95{\%}CI 1.1-17.9]; p = 0.015). We found no association between MTBc families and second-line drug resistance profiles (p > 0.05). Our findings show that MDR-TB in Niger is caused by major spoligotypes of the Euro-American L4; with more rapid smear and culture conversion in patients infected with the Cameroon family. These first insights may alert clinicians that slow conversion may be associated with the type of infecting strain.",
author = "Mebrat Ejo and Souleymane Hassane-Harouna and Souleymane, {Mahamadou Bassirou} and Pauline Lempens and Jeroen Dockx and Cecile Uwizeye and {De Rijk}, Pim and Tom Decroo and Ermias Diro and Gabriela Torrea and Leen Rigouts and Alberto Piubello and {de Jong}, {Bouke C}",
note = "CPDF; Copyright {\circledC} 2020. Published by Elsevier Ltd.",
year = "2020",
doi = "10.1016/j.tube.2020.101922",
language = "English",
volume = "122",
journal = "Tuberculosis",
issn = "1472-9792",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - Multidrug-resistant patients receiving treatment in Niger who are infected with M. tuberculosis Cameroon family convert faster in smear and culture than those with M. tuberculosis Ghana family

AU - Ejo, Mebrat

AU - Hassane-Harouna, Souleymane

AU - Souleymane, Mahamadou Bassirou

AU - Lempens, Pauline

AU - Dockx, Jeroen

AU - Uwizeye, Cecile

AU - De Rijk, Pim

AU - Decroo, Tom

AU - Diro, Ermias

AU - Torrea, Gabriela

AU - Rigouts, Leen

AU - Piubello, Alberto

AU - de Jong, Bouke C

N1 - CPDF; Copyright © 2020. Published by Elsevier Ltd.

PY - 2020

Y1 - 2020

N2 - In this study, we analyzed the M. tuberculosis complex (MTBc) population structure among multidrug-resistant TB (MDR-TB) patients in Niger and tested whether the Cameroon family displayed a slower response to MDR-TB treatment. We genotyped baseline clinical isolates that had been collected from pulmonary MDR-TB patients recruited consecutively between 2008 and 2016 in Niger. Spoligotyping was used to analyze the genetic diversity of mycobacterial lineages, and Kaplan Meier's analysis to compare treatment outcomes. A total of 222 MTBc isolates were genotyped; 204 (91,9%) were identified as the Euro-American L4 lineage, with the Ghana family (106, 47,4%) and the Cameroon family (63, 28,4%) being predominant. Patients infected by Cameroon family isolates 61(96,8%) showed faster conversion (log-rank p < 0.01) than those infected with Ghana family isolates (91,5%), and were more likely to experience favorable outcome (adjusted odds ratio [aOR] 4.4; 95%CI 1.1-17.9]; p = 0.015). We found no association between MTBc families and second-line drug resistance profiles (p > 0.05). Our findings show that MDR-TB in Niger is caused by major spoligotypes of the Euro-American L4; with more rapid smear and culture conversion in patients infected with the Cameroon family. These first insights may alert clinicians that slow conversion may be associated with the type of infecting strain.

AB - In this study, we analyzed the M. tuberculosis complex (MTBc) population structure among multidrug-resistant TB (MDR-TB) patients in Niger and tested whether the Cameroon family displayed a slower response to MDR-TB treatment. We genotyped baseline clinical isolates that had been collected from pulmonary MDR-TB patients recruited consecutively between 2008 and 2016 in Niger. Spoligotyping was used to analyze the genetic diversity of mycobacterial lineages, and Kaplan Meier's analysis to compare treatment outcomes. A total of 222 MTBc isolates were genotyped; 204 (91,9%) were identified as the Euro-American L4 lineage, with the Ghana family (106, 47,4%) and the Cameroon family (63, 28,4%) being predominant. Patients infected by Cameroon family isolates 61(96,8%) showed faster conversion (log-rank p < 0.01) than those infected with Ghana family isolates (91,5%), and were more likely to experience favorable outcome (adjusted odds ratio [aOR] 4.4; 95%CI 1.1-17.9]; p = 0.015). We found no association between MTBc families and second-line drug resistance profiles (p > 0.05). Our findings show that MDR-TB in Niger is caused by major spoligotypes of the Euro-American L4; with more rapid smear and culture conversion in patients infected with the Cameroon family. These first insights may alert clinicians that slow conversion may be associated with the type of infecting strain.

U2 - 10.1016/j.tube.2020.101922

DO - 10.1016/j.tube.2020.101922

M3 - A1: Web of Science-article

C2 - 32275231

VL - 122

JO - Tuberculosis

JF - Tuberculosis

SN - 1472-9792

M1 - 101922

ER -

ID: 3365672