Standard

Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study. / Respiratory Virus Global Epidemiology Network.

In: The Lancet. Global health, Vol. 8, Nr. 4, 2020, blz. e497-e510.

Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikel

Harvard

APA

Vancouver

Author

Respiratory Virus Global Epidemiology Network. / Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study. In: The Lancet. Global health. 2020 ; Vol. 8, Nr. 4. blz. e497-e510.

BibTeX

@article{7a8d2b5da78f4158a82163f932e481c2,
title = "Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study",
abstract = "BACKGROUND: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018.METHODS: We estimated the regional and global burden of influenza-associated respiratory infections in children under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec 31, 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to assess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths from influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of influenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on the number of in-hospital deaths, US paediatric influenza-associated death data, and population-based childhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income countries.FINDINGS: In 2018, among children under 5 years globally, there were an estimated 109·5 million influenza virus episodes (uncertainty range [UR] 63·1-190·6), 10·1 million influenza-virus-associated ALRI cases (6·8-15·1); 870 000 influenza-virus-associated ALRI hospital admissions (543 000-1 415 000), 15 300 in-hospital deaths (5800-43 800), and up to 34 800 (13 200-97 200) overall influenza-virus-associated ALRI deaths. Influenza virus accounted for 7{\%} of ALRI cases, 5{\%} of ALRI hospital admissions, and 4{\%} of ALRI deaths in children under 5 years. About 23{\%} of the hospital admissions and 36{\%} of the in-hospital deaths were in infants under 6 months. About 82{\%} of the in-hospital deaths occurred in low-income and lower-middle-income countries.INTERPRETATION: A large proportion of the influenza-associated burden occurs among young infants and in low-income and lower middle-income countries. Our findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and middle-income countries.FUNDING: WHO; Bill & Melinda Gates Foundation.",
author = "{Respiratory Virus Global Epidemiology Network} and Xin Wang and You Li and O'Brien, {Katherine L} and Madhi, {Shabir A} and Marc-Alain Widdowson and Peter Byass and Omer, {Saad B} and Qalab Abbas and Asad Ali and Alberta Amu and Eduardo Azziz-Baumgartner and Quique Bassat and {Abdullah Brooks}, W and Chaves, {Sandra S} and Alexandria Chung and Cheryl Cohen and Marcela Echavarria and Fasce, {Rodrigo A} and Angela Gentile and Aubree Gordon and Michelle Groome and Terho Heikkinen and Siddhivinayak Hirve and Jara, {Jorge H} and Katz, {Mark A} and Najwa Khuri-Bulos and Anand Krishnan and {de Leon}, Oscar and Lucero, {Marilla G} and McCracken, {John P} and Ainara Mira-Iglesias and Mo{\"i}si, {Jennifer C} and Munywoki, {Patrick K} and Millogo Ourohir{\'e} and Polack, {Fernando P} and Manveer Rahi and Rasmussen, {Zeba A} and Rath, {Barbara A} and Saha, {Samir K} and Sim{\~o}es, {Eric Af} and Viviana Sotomayor and Somsak Thamthitiwat and Treurnicht, {Florette K} and Marylene Wamukoya and Lay-Myint Yoshida and Zar, {Heather J} and Harry Campbell and Harish Nair",
note = "CPDF; Copyright {\circledC} 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.",
year = "2020",
doi = "10.1016/S2214-109X(19)30545-5",
language = "English",
volume = "8",
pages = "e497--e510",
journal = "Lancet Global Health",
issn = "2214-109X",
publisher = "ELSEVIER SCI LTD",
number = "4",

}

RIS

TY - JOUR

T1 - Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

AU - Respiratory Virus Global Epidemiology Network

AU - Wang, Xin

AU - Li, You

AU - O'Brien, Katherine L

AU - Madhi, Shabir A

AU - Widdowson, Marc-Alain

AU - Byass, Peter

AU - Omer, Saad B

AU - Abbas, Qalab

AU - Ali, Asad

AU - Amu, Alberta

AU - Azziz-Baumgartner, Eduardo

AU - Bassat, Quique

AU - Abdullah Brooks, W

AU - Chaves, Sandra S

AU - Chung, Alexandria

AU - Cohen, Cheryl

AU - Echavarria, Marcela

AU - Fasce, Rodrigo A

AU - Gentile, Angela

AU - Gordon, Aubree

AU - Groome, Michelle

AU - Heikkinen, Terho

AU - Hirve, Siddhivinayak

AU - Jara, Jorge H

AU - Katz, Mark A

AU - Khuri-Bulos, Najwa

AU - Krishnan, Anand

AU - de Leon, Oscar

AU - Lucero, Marilla G

AU - McCracken, John P

AU - Mira-Iglesias, Ainara

AU - Moïsi, Jennifer C

AU - Munywoki, Patrick K

AU - Ourohiré, Millogo

AU - Polack, Fernando P

AU - Rahi, Manveer

AU - Rasmussen, Zeba A

AU - Rath, Barbara A

AU - Saha, Samir K

AU - Simões, Eric Af

AU - Sotomayor, Viviana

AU - Thamthitiwat, Somsak

AU - Treurnicht, Florette K

AU - Wamukoya, Marylene

AU - Yoshida, Lay-Myint

AU - Zar, Heather J

AU - Campbell, Harry

AU - Nair, Harish

N1 - CPDF; Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018.METHODS: We estimated the regional and global burden of influenza-associated respiratory infections in children under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec 31, 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to assess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths from influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of influenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on the number of in-hospital deaths, US paediatric influenza-associated death data, and population-based childhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income countries.FINDINGS: In 2018, among children under 5 years globally, there were an estimated 109·5 million influenza virus episodes (uncertainty range [UR] 63·1-190·6), 10·1 million influenza-virus-associated ALRI cases (6·8-15·1); 870 000 influenza-virus-associated ALRI hospital admissions (543 000-1 415 000), 15 300 in-hospital deaths (5800-43 800), and up to 34 800 (13 200-97 200) overall influenza-virus-associated ALRI deaths. Influenza virus accounted for 7% of ALRI cases, 5% of ALRI hospital admissions, and 4% of ALRI deaths in children under 5 years. About 23% of the hospital admissions and 36% of the in-hospital deaths were in infants under 6 months. About 82% of the in-hospital deaths occurred in low-income and lower-middle-income countries.INTERPRETATION: A large proportion of the influenza-associated burden occurs among young infants and in low-income and lower middle-income countries. Our findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and middle-income countries.FUNDING: WHO; Bill & Melinda Gates Foundation.

AB - BACKGROUND: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018.METHODS: We estimated the regional and global burden of influenza-associated respiratory infections in children under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec 31, 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to assess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths from influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of influenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on the number of in-hospital deaths, US paediatric influenza-associated death data, and population-based childhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income countries.FINDINGS: In 2018, among children under 5 years globally, there were an estimated 109·5 million influenza virus episodes (uncertainty range [UR] 63·1-190·6), 10·1 million influenza-virus-associated ALRI cases (6·8-15·1); 870 000 influenza-virus-associated ALRI hospital admissions (543 000-1 415 000), 15 300 in-hospital deaths (5800-43 800), and up to 34 800 (13 200-97 200) overall influenza-virus-associated ALRI deaths. Influenza virus accounted for 7% of ALRI cases, 5% of ALRI hospital admissions, and 4% of ALRI deaths in children under 5 years. About 23% of the hospital admissions and 36% of the in-hospital deaths were in infants under 6 months. About 82% of the in-hospital deaths occurred in low-income and lower-middle-income countries.INTERPRETATION: A large proportion of the influenza-associated burden occurs among young infants and in low-income and lower middle-income countries. Our findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and middle-income countries.FUNDING: WHO; Bill & Melinda Gates Foundation.

U2 - 10.1016/S2214-109X(19)30545-5

DO - 10.1016/S2214-109X(19)30545-5

M3 - A1: Web of Science-article

C2 - 32087815

VL - 8

SP - e497-e510

JO - Lancet Global Health

JF - Lancet Global Health

SN - 2214-109X

IS - 4

ER -

ID: 3243003