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Common causes of EID sample rejection in Zimbabwe and how to mitigate them. / Chiku, Charles; Zolfo, Maria; Senkoro, Mbazi; Mabhala, Mzwandile; Tweya, Hannock; Musasa, Patience; Shukusho, Fungai D; Mazarura, Exervia; Mushavi, Angela; Mangwanya, Douglas.

In: PLoS ONE, Vol. 14, Nr. 8, 2019, blz. e0210136.

Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikelOnderzoekpeer review

Harvard

Chiku, C, Zolfo, M, Senkoro, M, Mabhala, M, Tweya, H, Musasa, P, Shukusho, FD, Mazarura, E, Mushavi, A & Mangwanya, D 2019, 'Common causes of EID sample rejection in Zimbabwe and how to mitigate them' PLoS ONE, vol. 14, nr. 8, blz. e0210136. https://doi.org/10.1371/journal.pone.0210136

APA

Chiku, C., Zolfo, M., Senkoro, M., Mabhala, M., Tweya, H., Musasa, P., ... Mangwanya, D. (2019). Common causes of EID sample rejection in Zimbabwe and how to mitigate them. PLoS ONE, 14(8), e0210136. https://doi.org/10.1371/journal.pone.0210136

Vancouver

Chiku C, Zolfo M, Senkoro M, Mabhala M, Tweya H, Musasa P et al. Common causes of EID sample rejection in Zimbabwe and how to mitigate them. PLoS ONE. 2019;14(8):e0210136. https://doi.org/10.1371/journal.pone.0210136

Author

Chiku, Charles ; Zolfo, Maria ; Senkoro, Mbazi ; Mabhala, Mzwandile ; Tweya, Hannock ; Musasa, Patience ; Shukusho, Fungai D ; Mazarura, Exervia ; Mushavi, Angela ; Mangwanya, Douglas. / Common causes of EID sample rejection in Zimbabwe and how to mitigate them. In: PLoS ONE. 2019 ; Vol. 14, Nr. 8. blz. e0210136.

BibTeX

@article{eb5d5a5bd07f4994afd7be1ba6a39cdf,
title = "Common causes of EID sample rejection in Zimbabwe and how to mitigate them",
abstract = "Early infant diagnosis (EID) of HIV provides an opportunity for early HIV detection and access to appropriate Antiretroviral treatment (ART). Dried Blood Spot (DBS) samples are used for EID of exposed infants, born to HIV-positive mothers. However, DBS rejection rates in Zimbabwe have been exceeding the target of less than 2{\%} per month set by the National Microbiology Reference Laboratory (NMRL), in Harare. The aim of this study was to determine the DBS sample rejection rate, the reasons for rejection and the possible associations between rejection and level of health facility where the samples were collected. This is an analytical cross-sectional study using routine DBS sample data from the NMRL in Harare, Zimbabwe, between January and December 2017.A total of 34 950 DBS samples were received at the NMRL. Of these, 1291(4{\%}) were rejected. Reasons for rejection were insufficient specimen volume (72{\%}), missing request form (11{\%}), missing sample (6{\%}), cross-contamination (6{\%}), mismatch of information (4{\%}) and clotted sample (1{\%}). Samples collected from clinics/rural health facilities were five times more likely to be rejected compared to those from a central hospital. Rejection rates were above the set target of <2{\%}. The reasons for rejection were 'pre-analytical' errors including labelling errors, missing or inconsistent data, and insufficient blood collected. Samples collected at primary healthcare facilities had higher rejection rates.",
author = "Charles Chiku and Maria Zolfo and Mbazi Senkoro and Mzwandile Mabhala and Hannock Tweya and Patience Musasa and Shukusho, {Fungai D} and Exervia Mazarura and Angela Mushavi and Douglas Mangwanya",
note = "CPDF",
year = "2019",
doi = "10.1371/journal.pone.0210136",
language = "English",
volume = "14",
pages = "e0210136",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - Common causes of EID sample rejection in Zimbabwe and how to mitigate them

AU - Chiku, Charles

AU - Zolfo, Maria

AU - Senkoro, Mbazi

AU - Mabhala, Mzwandile

AU - Tweya, Hannock

AU - Musasa, Patience

AU - Shukusho, Fungai D

AU - Mazarura, Exervia

AU - Mushavi, Angela

AU - Mangwanya, Douglas

N1 - CPDF

PY - 2019

Y1 - 2019

N2 - Early infant diagnosis (EID) of HIV provides an opportunity for early HIV detection and access to appropriate Antiretroviral treatment (ART). Dried Blood Spot (DBS) samples are used for EID of exposed infants, born to HIV-positive mothers. However, DBS rejection rates in Zimbabwe have been exceeding the target of less than 2% per month set by the National Microbiology Reference Laboratory (NMRL), in Harare. The aim of this study was to determine the DBS sample rejection rate, the reasons for rejection and the possible associations between rejection and level of health facility where the samples were collected. This is an analytical cross-sectional study using routine DBS sample data from the NMRL in Harare, Zimbabwe, between January and December 2017.A total of 34 950 DBS samples were received at the NMRL. Of these, 1291(4%) were rejected. Reasons for rejection were insufficient specimen volume (72%), missing request form (11%), missing sample (6%), cross-contamination (6%), mismatch of information (4%) and clotted sample (1%). Samples collected from clinics/rural health facilities were five times more likely to be rejected compared to those from a central hospital. Rejection rates were above the set target of <2%. The reasons for rejection were 'pre-analytical' errors including labelling errors, missing or inconsistent data, and insufficient blood collected. Samples collected at primary healthcare facilities had higher rejection rates.

AB - Early infant diagnosis (EID) of HIV provides an opportunity for early HIV detection and access to appropriate Antiretroviral treatment (ART). Dried Blood Spot (DBS) samples are used for EID of exposed infants, born to HIV-positive mothers. However, DBS rejection rates in Zimbabwe have been exceeding the target of less than 2% per month set by the National Microbiology Reference Laboratory (NMRL), in Harare. The aim of this study was to determine the DBS sample rejection rate, the reasons for rejection and the possible associations between rejection and level of health facility where the samples were collected. This is an analytical cross-sectional study using routine DBS sample data from the NMRL in Harare, Zimbabwe, between January and December 2017.A total of 34 950 DBS samples were received at the NMRL. Of these, 1291(4%) were rejected. Reasons for rejection were insufficient specimen volume (72%), missing request form (11%), missing sample (6%), cross-contamination (6%), mismatch of information (4%) and clotted sample (1%). Samples collected from clinics/rural health facilities were five times more likely to be rejected compared to those from a central hospital. Rejection rates were above the set target of <2%. The reasons for rejection were 'pre-analytical' errors including labelling errors, missing or inconsistent data, and insufficient blood collected. Samples collected at primary healthcare facilities had higher rejection rates.

U2 - 10.1371/journal.pone.0210136

DO - 10.1371/journal.pone.0210136

M3 - A1: Web of Science-article

VL - 14

SP - e0210136

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 8

ER -

ID: 3037114