• G. S. A. Smit
  • S. Abrams
  • P. Dorny
  • N. Speybroeck
  • B. Devleesschauwer
  • V Hutse
  • H. Jansens
  • H. Theeten
  • P. Beutels
  • N. Hens

Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31-34%) in 2002 and 31% (95% CI 30-32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort.

Original languageEnglish
Article number154
JournalEpidemiology and Infection
Pages (from-to)e154
Number of pages9
Publication statusPublished - 2019

Bibliographical note


    Research areas

  • Cytomegalovirus, hepatitis A virus, estimating age and birth cohort-specific seroprevalence, seroincidence, mixture modelling, WANING IMMUNITY, MIXTURE-MODELS, SEROEPIDEMIOLOGY, ANTIBODY, RUBELLA, PREVALENCE, VACCINATION, PERTUSSIS, EPIDEMIC, ENGLAND

ID: 3014507