DOI

Mass spectrometry-based proteomics has been extensively used to map bacterial proteomes, which has led to a better understanding of the molecular mechanisms underlying bacterial infection and bacteria-host interactions. Quantitative proteomics using selected or parallel reaction monitoring is considered one of the most sensitive and specific quantitative MS-based approaches and has significantly advanced proteome studies of pathogenic bacteria. Here, recent applications of targeted proteomics for bacteria identification, biomarker discovery, and the characterization of bacterial virulence and antimicrobial resistance are reviewed among others. Results of such studies are expected to further contribute to improve the fight against the most common human pathogenic bacteria.

Original languageEnglish
Article number1800435
JournalProteomics
Number of pages10
ISSN1615-9853
DOIs
Publication statusPublished - 2019

Bibliographical note

CPDF

    Research areas

  • antibiotic resistance, bacteria, biomarkers, targeted proteomics, virulence, DATA-INDEPENDENT ACQUISITION, BACILLUS-ANTHRACIS SPORES, H BINDING-PROTEIN, MASS-SPECTROMETRY, ESCHERICHIA-COLI, MYCOBACTERIUM-TUBERCULOSIS, STREPTOCOCCUS-PYOGENES, STAPHYLOCOCCUS-AUREUS, HIGH-RESOLUTION, GLOBAL BURDEN

ID: 3026697