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Reliable serological diagnostic tests for arboviruses: feasible or utopia? / Kerkhof, Karen; Falconi-Agapito, Francesca; Van Esbroeck, Marjan; Talledo, Michael; Ariën, Kevin K.

In: Trends in Microbiology, Vol. 28, No. 4, 2020, p. 276-292.

Research output: Contribution to journalA1: Web of Science-article

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@article{a56f55f94e3d4eccbc0ce2cce8ffcc38,
title = "Reliable serological diagnostic tests for arboviruses: feasible or utopia?",
abstract = "Infections with arthropod-borne viruses are increasing globally as a result of climate and demographic changes, global dispersion of insect vectors, and increased air travel. The similar symptomatology of arboviral diseases and the cocirculation of different arboviruses in Africa, Asia, and South America complicate diagnosis. Despite the high sensitivity and specificity of molecular diagnostic tests, their utility is limited to the short viremic phase of arbovirus infections, and therefore the diagnosis of infection is frequently missed in clinical practice. Conversely, the duration of antibody responses provides a wider window of opportunity, making diagnosis more dependent on IgM/IgG detection. This review discusses the issues underlying the low specificity of antibody-detection assays, and addresses the challenges and strategies for discovering more specific biomarkers to enable a more accurate diagnosis.",
author = "Karen Kerkhof and Francesca Falconi-Agapito and {Van Esbroeck}, Marjan and Michael Talledo and Ari{\"e}n, {Kevin K}",
note = "CPDF; Copyright {\circledC} 2019 Elsevier Ltd. All rights reserved.",
year = "2020",
doi = "10.1016/j.tim.2019.11.005",
language = "English",
volume = "28",
pages = "276--292",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "4",

}

RIS

TY - JOUR

T1 - Reliable serological diagnostic tests for arboviruses: feasible or utopia?

AU - Kerkhof, Karen

AU - Falconi-Agapito, Francesca

AU - Van Esbroeck, Marjan

AU - Talledo, Michael

AU - Ariën, Kevin K

N1 - CPDF; Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2020

Y1 - 2020

N2 - Infections with arthropod-borne viruses are increasing globally as a result of climate and demographic changes, global dispersion of insect vectors, and increased air travel. The similar symptomatology of arboviral diseases and the cocirculation of different arboviruses in Africa, Asia, and South America complicate diagnosis. Despite the high sensitivity and specificity of molecular diagnostic tests, their utility is limited to the short viremic phase of arbovirus infections, and therefore the diagnosis of infection is frequently missed in clinical practice. Conversely, the duration of antibody responses provides a wider window of opportunity, making diagnosis more dependent on IgM/IgG detection. This review discusses the issues underlying the low specificity of antibody-detection assays, and addresses the challenges and strategies for discovering more specific biomarkers to enable a more accurate diagnosis.

AB - Infections with arthropod-borne viruses are increasing globally as a result of climate and demographic changes, global dispersion of insect vectors, and increased air travel. The similar symptomatology of arboviral diseases and the cocirculation of different arboviruses in Africa, Asia, and South America complicate diagnosis. Despite the high sensitivity and specificity of molecular diagnostic tests, their utility is limited to the short viremic phase of arbovirus infections, and therefore the diagnosis of infection is frequently missed in clinical practice. Conversely, the duration of antibody responses provides a wider window of opportunity, making diagnosis more dependent on IgM/IgG detection. This review discusses the issues underlying the low specificity of antibody-detection assays, and addresses the challenges and strategies for discovering more specific biomarkers to enable a more accurate diagnosis.

U2 - 10.1016/j.tim.2019.11.005

DO - 10.1016/j.tim.2019.11.005

M3 - A1: Web of Science-article

C2 - 31864844

VL - 28

SP - 276

EP - 292

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 4

ER -

ID: 3178376