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Population-based incidence of severe acute respiratory virus infections among children aged. / Nasreen, Sharifa; Luby, Stephen P; Brooks, W Abdullah; Homaira, Nusrat; Al Mamun, Abdullah; Bhuiyan, Mejbah Uddin; Rahman, Mustafizur; Ahmed, Dilruba; Abedin, Jaynal; Rahman, Mahmudur; Alamgir, A S M; Fry, Alicia M; Streatfield, Peter Kim; Rahman, Anisur; Bresee, Joseph; Widdowson, Marc-Alain; Azziz-Baumgartner, Eduardo.

In: PLoS ONE, Vol. 9, No. 2, 2014, p. e89978.

Research output: Contribution to journalArticle

Harvard

Nasreen, S, Luby, SP, Brooks, WA, Homaira, N, Al Mamun, A, Bhuiyan, MU, Rahman, M, Ahmed, D, Abedin, J, Rahman, M, Alamgir, ASM, Fry, AM, Streatfield, PK, Rahman, A, Bresee, J, Widdowson, M-A & Azziz-Baumgartner, E 2014, 'Population-based incidence of severe acute respiratory virus infections among children aged', PLoS ONE, vol. 9, no. 2, pp. e89978. https://doi.org/10.1371/journal.pone.0089978

APA

Nasreen, S., Luby, S. P., Brooks, W. A., Homaira, N., Al Mamun, A., Bhuiyan, M. U., ... Azziz-Baumgartner, E. (2014). Population-based incidence of severe acute respiratory virus infections among children aged. PLoS ONE, 9(2), e89978. https://doi.org/10.1371/journal.pone.0089978

Vancouver

Nasreen S, Luby SP, Brooks WA, Homaira N, Al Mamun A, Bhuiyan MU et al. Population-based incidence of severe acute respiratory virus infections among children aged. PLoS ONE. 2014;9(2):e89978. https://doi.org/10.1371/journal.pone.0089978

Author

Nasreen, Sharifa ; Luby, Stephen P ; Brooks, W Abdullah ; Homaira, Nusrat ; Al Mamun, Abdullah ; Bhuiyan, Mejbah Uddin ; Rahman, Mustafizur ; Ahmed, Dilruba ; Abedin, Jaynal ; Rahman, Mahmudur ; Alamgir, A S M ; Fry, Alicia M ; Streatfield, Peter Kim ; Rahman, Anisur ; Bresee, Joseph ; Widdowson, Marc-Alain ; Azziz-Baumgartner, Eduardo. / Population-based incidence of severe acute respiratory virus infections among children aged. In: PLoS ONE. 2014 ; Vol. 9, No. 2. pp. e89978.

BibTeX

@article{ccefd32647dc47abbccc6bc89367a137,
title = "Population-based incidence of severe acute respiratory virus infections among children aged",
abstract = "BACKGROUND: Better understanding the etiology-specific incidence of severe acute respiratory infections (SARIs) in resource-poor, rural settings will help further develop and prioritize prevention strategies. To address this gap in knowledge, we conducted a longitudinal study to estimate the incidence of SARIs among children in rural Bangladesh.METHODS: During June through October 2010, we followed children aged <5 years in 67 villages to identify those with cough, difficulty breathing, age-specific tachypnea and/or danger signs in the community or admitted to the local hospital. A study physician collected clinical information and obtained nasopharyngeal swabs from all SARI cases and blood for bacterial culture from those hospitalized. We tested swabs for respiratory syncytial virus (RSV), influenza viruses, human metapneumoviruses, adenoviruses and human parainfluenza viruses 1-3 (HPIV) by real-time reverse transcription polymerase chain reaction. We calculated virus-specific SARI incidence by dividing the number of new illnesses by the person-time each child contributed to the study.RESULTS: We followed 12,850 children for 279,029 person-weeks (pw) and identified 141 SARI cases; 76 (54{\%}) at their homes and 65 (46{\%}) at the hospital. RSV was associated with 7.9 SARI hospitalizations per 100,000 pw, HPIV3 2.2 hospitalizations/100,000 pw, and influenza 1.1 hospitalizations/100,000 pw. Among non-hospitalized SARI cases, RSV was associated with 10.8 illnesses/100,000 pw, HPIV3 1.8/100,000 pw, influenza 1.4/100,000 pw, and adenoviruses 0.4/100,000 pw.CONCLUSION: Respiratory viruses, particularly RSV, were commonly associated with SARI among children. It may be useful to explore the value of investing in prevention strategies, such as handwashing and respiratory hygiene, to reduce respiratory infections among young children in such settings.",
keywords = "Bangladesh/epidemiology, Child, Preschool, Disease Outbreaks/history, History, 21st Century, Humans, Incidence, Infant, Longitudinal Studies, Orthomyxoviridae/genetics, Parainfluenza Virus 1, Human/genetics, Parainfluenza Virus 2, Human/genetics, Parainfluenza Virus 3, Human/genetics, RNA Virus Infections/epidemiology, Real-Time Polymerase Chain Reaction, Respiratory Syncytial Viruses/genetics, Respiratory Tract Infections/epidemiology, Reverse Transcriptase Polymerase Chain Reaction, Statistics, Nonparametric",
author = "Sharifa Nasreen and Luby, {Stephen P} and Brooks, {W Abdullah} and Nusrat Homaira and {Al Mamun}, Abdullah and Bhuiyan, {Mejbah Uddin} and Mustafizur Rahman and Dilruba Ahmed and Jaynal Abedin and Mahmudur Rahman and Alamgir, {A S M} and Fry, {Alicia M} and Streatfield, {Peter Kim} and Anisur Rahman and Joseph Bresee and Marc-Alain Widdowson and Eduardo Azziz-Baumgartner",
year = "2014",
doi = "10.1371/journal.pone.0089978",
language = "English",
volume = "9",
pages = "e89978",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Population-based incidence of severe acute respiratory virus infections among children aged

AU - Nasreen, Sharifa

AU - Luby, Stephen P

AU - Brooks, W Abdullah

AU - Homaira, Nusrat

AU - Al Mamun, Abdullah

AU - Bhuiyan, Mejbah Uddin

AU - Rahman, Mustafizur

AU - Ahmed, Dilruba

AU - Abedin, Jaynal

AU - Rahman, Mahmudur

AU - Alamgir, A S M

AU - Fry, Alicia M

AU - Streatfield, Peter Kim

AU - Rahman, Anisur

AU - Bresee, Joseph

AU - Widdowson, Marc-Alain

AU - Azziz-Baumgartner, Eduardo

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Better understanding the etiology-specific incidence of severe acute respiratory infections (SARIs) in resource-poor, rural settings will help further develop and prioritize prevention strategies. To address this gap in knowledge, we conducted a longitudinal study to estimate the incidence of SARIs among children in rural Bangladesh.METHODS: During June through October 2010, we followed children aged <5 years in 67 villages to identify those with cough, difficulty breathing, age-specific tachypnea and/or danger signs in the community or admitted to the local hospital. A study physician collected clinical information and obtained nasopharyngeal swabs from all SARI cases and blood for bacterial culture from those hospitalized. We tested swabs for respiratory syncytial virus (RSV), influenza viruses, human metapneumoviruses, adenoviruses and human parainfluenza viruses 1-3 (HPIV) by real-time reverse transcription polymerase chain reaction. We calculated virus-specific SARI incidence by dividing the number of new illnesses by the person-time each child contributed to the study.RESULTS: We followed 12,850 children for 279,029 person-weeks (pw) and identified 141 SARI cases; 76 (54%) at their homes and 65 (46%) at the hospital. RSV was associated with 7.9 SARI hospitalizations per 100,000 pw, HPIV3 2.2 hospitalizations/100,000 pw, and influenza 1.1 hospitalizations/100,000 pw. Among non-hospitalized SARI cases, RSV was associated with 10.8 illnesses/100,000 pw, HPIV3 1.8/100,000 pw, influenza 1.4/100,000 pw, and adenoviruses 0.4/100,000 pw.CONCLUSION: Respiratory viruses, particularly RSV, were commonly associated with SARI among children. It may be useful to explore the value of investing in prevention strategies, such as handwashing and respiratory hygiene, to reduce respiratory infections among young children in such settings.

AB - BACKGROUND: Better understanding the etiology-specific incidence of severe acute respiratory infections (SARIs) in resource-poor, rural settings will help further develop and prioritize prevention strategies. To address this gap in knowledge, we conducted a longitudinal study to estimate the incidence of SARIs among children in rural Bangladesh.METHODS: During June through October 2010, we followed children aged <5 years in 67 villages to identify those with cough, difficulty breathing, age-specific tachypnea and/or danger signs in the community or admitted to the local hospital. A study physician collected clinical information and obtained nasopharyngeal swabs from all SARI cases and blood for bacterial culture from those hospitalized. We tested swabs for respiratory syncytial virus (RSV), influenza viruses, human metapneumoviruses, adenoviruses and human parainfluenza viruses 1-3 (HPIV) by real-time reverse transcription polymerase chain reaction. We calculated virus-specific SARI incidence by dividing the number of new illnesses by the person-time each child contributed to the study.RESULTS: We followed 12,850 children for 279,029 person-weeks (pw) and identified 141 SARI cases; 76 (54%) at their homes and 65 (46%) at the hospital. RSV was associated with 7.9 SARI hospitalizations per 100,000 pw, HPIV3 2.2 hospitalizations/100,000 pw, and influenza 1.1 hospitalizations/100,000 pw. Among non-hospitalized SARI cases, RSV was associated with 10.8 illnesses/100,000 pw, HPIV3 1.8/100,000 pw, influenza 1.4/100,000 pw, and adenoviruses 0.4/100,000 pw.CONCLUSION: Respiratory viruses, particularly RSV, were commonly associated with SARI among children. It may be useful to explore the value of investing in prevention strategies, such as handwashing and respiratory hygiene, to reduce respiratory infections among young children in such settings.

KW - Bangladesh/epidemiology

KW - Child, Preschool

KW - Disease Outbreaks/history

KW - History, 21st Century

KW - Humans

KW - Incidence

KW - Infant

KW - Longitudinal Studies

KW - Orthomyxoviridae/genetics

KW - Parainfluenza Virus 1, Human/genetics

KW - Parainfluenza Virus 2, Human/genetics

KW - Parainfluenza Virus 3, Human/genetics

KW - RNA Virus Infections/epidemiology

KW - Real-Time Polymerase Chain Reaction

KW - Respiratory Syncytial Viruses/genetics

KW - Respiratory Tract Infections/epidemiology

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Statistics, Nonparametric

U2 - 10.1371/journal.pone.0089978

DO - 10.1371/journal.pone.0089978

M3 - Article

C2 - 24587163

VL - 9

SP - e89978

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

ER -

ID: 3254565