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@article{44ae87ac923d4efdb5828fb8c47a606c,
title = "Incidence of Zika virus infection in a prospective cohort of Belgian travelers to the Americas in 2016",
abstract = "BACKGROUND: The incidence rate of Zika virus (ZIKV) infection in travelers from non-endemic areas to the Americas during the ZIKV outbreak in 2016 is unknown.METHODS: We prospectively recruited Belgian adults, who planned to travel to South America (SAM), Central America (CAM) and the Caribbean (CAR), to study the incidence and characteristics of ZIKV. We collected demographic data and sera at baseline. We trained participants to collect capillary blood on filter paper (BFP). When ill during travel, the participants completed a questionnaire and they sampled BFP for post-hoc analysis. All symptomatic participants were screened for ZIKV using ZIKV-specific RT-PCR on serum or urine, or BFP, and antibody detection assays (ELISA). Follow-up sera of asymptomatic travelers, obtained at least 20days post-travel, were tested with ZIKV ELISA only. All positive ELISA results were subject to confirmation by Virus Neutralization Testing (VNT).RESULTS: Forty-nine participants completed follow-up, 38 women and 11 men, age 32 years (median, range 19-64). Travel destinations were countries in SAM (n=20), CAM (n=24) and CAR (n=5). The total travel duration was 67.8 person-months. Illness was reported by 24 participants (49.0{\%}). ZIKV infection was confirmed in 9 cases, by RT-PCR (n=5) and by VNT (n=4). Only one of 9 ZIKV-cases (11.1{\%}) was asymptomatic. The ZIKV incidence rate was 17.0{\%} (95{\%}CI [7.8-32.2]) per month of travel.CONCLUSIONS: The ZIKV incidence rate in adult travelers from non-endemic countries to the epidemic territories during the 2016 outbreak was high. Asymptomatic ZIKV infection was rare in this population.",
author = "Ralph Huits and {Van Den Bossche}, Dorien and Kaat Eggermont and Erica Lotgering and Anne-Marie Feyens and Idzi Potters and Jan Jacobs and {Van Esbroeck}, Marjan and Lieselotte Cnops and Emmanuel Bottieau",
note = "CPDF; CUNIT",
year = "2018",
doi = "10.1016/j.ijid.2018.10.010",
language = "English",
pages = "39--43",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "ELSEVIER SCI LTD",

}

RIS

TY - JOUR

T1 - Incidence of Zika virus infection in a prospective cohort of Belgian travelers to the Americas in 2016

AU - Huits, Ralph

AU - Van Den Bossche, Dorien

AU - Eggermont, Kaat

AU - Lotgering, Erica

AU - Feyens, Anne-Marie

AU - Potters, Idzi

AU - Jacobs, Jan

AU - Van Esbroeck, Marjan

AU - Cnops, Lieselotte

AU - Bottieau, Emmanuel

N1 - CPDF; CUNIT

PY - 2018

Y1 - 2018

N2 - BACKGROUND: The incidence rate of Zika virus (ZIKV) infection in travelers from non-endemic areas to the Americas during the ZIKV outbreak in 2016 is unknown.METHODS: We prospectively recruited Belgian adults, who planned to travel to South America (SAM), Central America (CAM) and the Caribbean (CAR), to study the incidence and characteristics of ZIKV. We collected demographic data and sera at baseline. We trained participants to collect capillary blood on filter paper (BFP). When ill during travel, the participants completed a questionnaire and they sampled BFP for post-hoc analysis. All symptomatic participants were screened for ZIKV using ZIKV-specific RT-PCR on serum or urine, or BFP, and antibody detection assays (ELISA). Follow-up sera of asymptomatic travelers, obtained at least 20days post-travel, were tested with ZIKV ELISA only. All positive ELISA results were subject to confirmation by Virus Neutralization Testing (VNT).RESULTS: Forty-nine participants completed follow-up, 38 women and 11 men, age 32 years (median, range 19-64). Travel destinations were countries in SAM (n=20), CAM (n=24) and CAR (n=5). The total travel duration was 67.8 person-months. Illness was reported by 24 participants (49.0%). ZIKV infection was confirmed in 9 cases, by RT-PCR (n=5) and by VNT (n=4). Only one of 9 ZIKV-cases (11.1%) was asymptomatic. The ZIKV incidence rate was 17.0% (95%CI [7.8-32.2]) per month of travel.CONCLUSIONS: The ZIKV incidence rate in adult travelers from non-endemic countries to the epidemic territories during the 2016 outbreak was high. Asymptomatic ZIKV infection was rare in this population.

AB - BACKGROUND: The incidence rate of Zika virus (ZIKV) infection in travelers from non-endemic areas to the Americas during the ZIKV outbreak in 2016 is unknown.METHODS: We prospectively recruited Belgian adults, who planned to travel to South America (SAM), Central America (CAM) and the Caribbean (CAR), to study the incidence and characteristics of ZIKV. We collected demographic data and sera at baseline. We trained participants to collect capillary blood on filter paper (BFP). When ill during travel, the participants completed a questionnaire and they sampled BFP for post-hoc analysis. All symptomatic participants were screened for ZIKV using ZIKV-specific RT-PCR on serum or urine, or BFP, and antibody detection assays (ELISA). Follow-up sera of asymptomatic travelers, obtained at least 20days post-travel, were tested with ZIKV ELISA only. All positive ELISA results were subject to confirmation by Virus Neutralization Testing (VNT).RESULTS: Forty-nine participants completed follow-up, 38 women and 11 men, age 32 years (median, range 19-64). Travel destinations were countries in SAM (n=20), CAM (n=24) and CAR (n=5). The total travel duration was 67.8 person-months. Illness was reported by 24 participants (49.0%). ZIKV infection was confirmed in 9 cases, by RT-PCR (n=5) and by VNT (n=4). Only one of 9 ZIKV-cases (11.1%) was asymptomatic. The ZIKV incidence rate was 17.0% (95%CI [7.8-32.2]) per month of travel.CONCLUSIONS: The ZIKV incidence rate in adult travelers from non-endemic countries to the epidemic territories during the 2016 outbreak was high. Asymptomatic ZIKV infection was rare in this population.

U2 - 10.1016/j.ijid.2018.10.010

DO - 10.1016/j.ijid.2018.10.010

M3 - A1: Web of Science-article

C2 - 30368020

SP - 39

EP - 43

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -

ID: 2741623