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@article{587a06a6db764f7cbd9052f5e1bb6a16,
title = "Choosing between daily and event-driven Pre-Exposure Prophylaxis: results of a Belgian PrEP demonstration project",
abstract = "BACKGROUND: Daily and event-driven Pre-Exposure Prophylaxis (PrEP) are efficacious in reducing HIV transmission among men who have sex with men (MSM). We analysed baseline data from a PrEP demonstration project 'Be-PrEP-ared' in Antwerp, Belgium to understand preferences for daily or event-driven PrEP among MSM at high risk for HIV, and factors influencing their initial choice.METHODS: Cross-sectional data from an open-label prospective cohort study, using mixed methods. Participants who pre-registered online were screened for eligibility and tested for sexually transmitted infections (STIs). Eligible participants chose between daily and event-driven PrEP and reported on behavioural data through an electronic questionnaire. In-depth interviews were conducted with a selected sub-sample. Bivariate associations were examined between preferred PrEP regimens and sociodemographic factors, sexual behaviour, and STIs at screening.RESULTS: In total, 200 participants were enrolled between October 2015 and December 2016. Self-reported levels of sexual risk-taking before enrolment were high. STI screening revealed that 39.5{\%} had at least one bacterial STI. At baseline, 76.5{\%} of participants preferred daily and 23.5{\%} event-driven PrEP. Feeling able to anticipate HIV risk was the most frequent reason for preferring event-driven PrEP. Regimen choice was associated with sexual risk-taking behaviour in the last three months. Almost all participants (95.7{\%}) considered it likely that they would change their dosing regimen the following year.CONCLUSION: Event-driven PrEP was preferred by 23.5{\%} of the participants, which better suits their preventive needs. Event-driven PrEP should be included in PrEP provision as a valuable alternative to daily PrEP for MSM at high risk for HIV.",
keywords = "PrEP, MSM, HIV prevention, event-driven PrEP, daily PrEP, HIV PREVENTION, MEN, SEX, INFECTION, DEMAND, ACCEPTABILITY, SAFETY, RISK",
author = "Thijs Reyniers and Christiana N{\"o}stlinger and Marie Laga and {De Baetselier}, Irith and Tania Crucitti and Kristien Wouters and Bart Smekens and Jozefien Buyze and Bea Vuylsteke",
note = "CPDF",
year = "2018",
doi = "10.1097/QAI.0000000000001791",
language = "English",
volume = "79",
pages = "186--194",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Choosing between daily and event-driven Pre-Exposure Prophylaxis: results of a Belgian PrEP demonstration project

AU - Reyniers, Thijs

AU - Nöstlinger, Christiana

AU - Laga, Marie

AU - De Baetselier, Irith

AU - Crucitti, Tania

AU - Wouters, Kristien

AU - Smekens, Bart

AU - Buyze, Jozefien

AU - Vuylsteke, Bea

N1 - CPDF

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Daily and event-driven Pre-Exposure Prophylaxis (PrEP) are efficacious in reducing HIV transmission among men who have sex with men (MSM). We analysed baseline data from a PrEP demonstration project 'Be-PrEP-ared' in Antwerp, Belgium to understand preferences for daily or event-driven PrEP among MSM at high risk for HIV, and factors influencing their initial choice.METHODS: Cross-sectional data from an open-label prospective cohort study, using mixed methods. Participants who pre-registered online were screened for eligibility and tested for sexually transmitted infections (STIs). Eligible participants chose between daily and event-driven PrEP and reported on behavioural data through an electronic questionnaire. In-depth interviews were conducted with a selected sub-sample. Bivariate associations were examined between preferred PrEP regimens and sociodemographic factors, sexual behaviour, and STIs at screening.RESULTS: In total, 200 participants were enrolled between October 2015 and December 2016. Self-reported levels of sexual risk-taking before enrolment were high. STI screening revealed that 39.5% had at least one bacterial STI. At baseline, 76.5% of participants preferred daily and 23.5% event-driven PrEP. Feeling able to anticipate HIV risk was the most frequent reason for preferring event-driven PrEP. Regimen choice was associated with sexual risk-taking behaviour in the last three months. Almost all participants (95.7%) considered it likely that they would change their dosing regimen the following year.CONCLUSION: Event-driven PrEP was preferred by 23.5% of the participants, which better suits their preventive needs. Event-driven PrEP should be included in PrEP provision as a valuable alternative to daily PrEP for MSM at high risk for HIV.

AB - BACKGROUND: Daily and event-driven Pre-Exposure Prophylaxis (PrEP) are efficacious in reducing HIV transmission among men who have sex with men (MSM). We analysed baseline data from a PrEP demonstration project 'Be-PrEP-ared' in Antwerp, Belgium to understand preferences for daily or event-driven PrEP among MSM at high risk for HIV, and factors influencing their initial choice.METHODS: Cross-sectional data from an open-label prospective cohort study, using mixed methods. Participants who pre-registered online were screened for eligibility and tested for sexually transmitted infections (STIs). Eligible participants chose between daily and event-driven PrEP and reported on behavioural data through an electronic questionnaire. In-depth interviews were conducted with a selected sub-sample. Bivariate associations were examined between preferred PrEP regimens and sociodemographic factors, sexual behaviour, and STIs at screening.RESULTS: In total, 200 participants were enrolled between October 2015 and December 2016. Self-reported levels of sexual risk-taking before enrolment were high. STI screening revealed that 39.5% had at least one bacterial STI. At baseline, 76.5% of participants preferred daily and 23.5% event-driven PrEP. Feeling able to anticipate HIV risk was the most frequent reason for preferring event-driven PrEP. Regimen choice was associated with sexual risk-taking behaviour in the last three months. Almost all participants (95.7%) considered it likely that they would change their dosing regimen the following year.CONCLUSION: Event-driven PrEP was preferred by 23.5% of the participants, which better suits their preventive needs. Event-driven PrEP should be included in PrEP provision as a valuable alternative to daily PrEP for MSM at high risk for HIV.

KW - PrEP

KW - MSM

KW - HIV prevention

KW - event-driven PrEP

KW - daily PrEP

KW - HIV PREVENTION

KW - MEN

KW - SEX

KW - INFECTION

KW - DEMAND

KW - ACCEPTABILITY

KW - SAFETY

KW - RISK

U2 - 10.1097/QAI.0000000000001791

DO - 10.1097/QAI.0000000000001791

M3 - A1: Web of Science-article

C2 - 29975211

VL - 79

SP - 186

EP - 194

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 2

ER -

ID: 2615892