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A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region. / Ngabonziza, Jean Claude Semuto; Loiseau, Chloé; Marceau, Michael; Jouet, Agathe; Menardo, Fabrizio; Tzfadia, Oren; Antoine, Rudy; Niyigena, Esdras Belamo; Mulders, Wim; Fissette, Kristina; Diels, Maren; Gaudin, Cyril; Duthoy, Stéphanie; Ssengooba, Willy; André, Emmanuel; Kaswa, Michel K; Habimana, Yves Mucyo; Brites, Daniela; Affolabi, Dissou; Mazarati, Jean Baptiste; de Jong, Bouke Catherine; Rigouts, Leen; Gagneux, Sebastien; Meehan, Conor Joseph; Supply, Philip.

In: Nature Communications, Vol. 11, No. 1, 2020, p. 2917.

Research output: Contribution to journalA1: Web of Science-article

Harvard

Ngabonziza, JCS, Loiseau, C, Marceau, M, Jouet, A, Menardo, F, Tzfadia, O, Antoine, R, Niyigena, EB, Mulders, W, Fissette, K, Diels, M, Gaudin, C, Duthoy, S, Ssengooba, W, André, E, Kaswa, MK, Habimana, YM, Brites, D, Affolabi, D, Mazarati, JB, de Jong, BC, Rigouts, L, Gagneux, S, Meehan, CJ & Supply, P 2020, 'A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region', Nature Communications, vol. 11, no. 1, pp. 2917. https://doi.org/10.1038/s41467-020-16626-6

APA

Ngabonziza, J. C. S., Loiseau, C., Marceau, M., Jouet, A., Menardo, F., Tzfadia, O., ... Supply, P. (2020). A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region. Nature Communications, 11(1), 2917. https://doi.org/10.1038/s41467-020-16626-6

Vancouver

Ngabonziza JCS, Loiseau C, Marceau M, Jouet A, Menardo F, Tzfadia O et al. A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region. Nature Communications. 2020;11(1):2917. https://doi.org/10.1038/s41467-020-16626-6

Author

Ngabonziza, Jean Claude Semuto ; Loiseau, Chloé ; Marceau, Michael ; Jouet, Agathe ; Menardo, Fabrizio ; Tzfadia, Oren ; Antoine, Rudy ; Niyigena, Esdras Belamo ; Mulders, Wim ; Fissette, Kristina ; Diels, Maren ; Gaudin, Cyril ; Duthoy, Stéphanie ; Ssengooba, Willy ; André, Emmanuel ; Kaswa, Michel K ; Habimana, Yves Mucyo ; Brites, Daniela ; Affolabi, Dissou ; Mazarati, Jean Baptiste ; de Jong, Bouke Catherine ; Rigouts, Leen ; Gagneux, Sebastien ; Meehan, Conor Joseph ; Supply, Philip. / A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region. In: Nature Communications. 2020 ; Vol. 11, No. 1. pp. 2917.

BibTeX

@article{c152bf7011364f189ff93164166f3978,
title = "A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region",
abstract = "The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.",
author = "Ngabonziza, {Jean Claude Semuto} and Chlo{\'e} Loiseau and Michael Marceau and Agathe Jouet and Fabrizio Menardo and Oren Tzfadia and Rudy Antoine and Niyigena, {Esdras Belamo} and Wim Mulders and Kristina Fissette and Maren Diels and Cyril Gaudin and St{\'e}phanie Duthoy and Willy Ssengooba and Emmanuel Andr{\'e} and Kaswa, {Michel K} and Habimana, {Yves Mucyo} and Daniela Brites and Dissou Affolabi and Mazarati, {Jean Baptiste} and {de Jong}, {Bouke Catherine} and Leen Rigouts and Sebastien Gagneux and Meehan, {Conor Joseph} and Philip Supply",
note = "CPDF",
year = "2020",
doi = "10.1038/s41467-020-16626-6",
language = "English",
volume = "11",
pages = "2917",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

AU - Ngabonziza, Jean Claude Semuto

AU - Loiseau, Chloé

AU - Marceau, Michael

AU - Jouet, Agathe

AU - Menardo, Fabrizio

AU - Tzfadia, Oren

AU - Antoine, Rudy

AU - Niyigena, Esdras Belamo

AU - Mulders, Wim

AU - Fissette, Kristina

AU - Diels, Maren

AU - Gaudin, Cyril

AU - Duthoy, Stéphanie

AU - Ssengooba, Willy

AU - André, Emmanuel

AU - Kaswa, Michel K

AU - Habimana, Yves Mucyo

AU - Brites, Daniela

AU - Affolabi, Dissou

AU - Mazarati, Jean Baptiste

AU - de Jong, Bouke Catherine

AU - Rigouts, Leen

AU - Gagneux, Sebastien

AU - Meehan, Conor Joseph

AU - Supply, Philip

N1 - CPDF

PY - 2020

Y1 - 2020

N2 - The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.

AB - The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.

U2 - 10.1038/s41467-020-16626-6

DO - 10.1038/s41467-020-16626-6

M3 - A1: Web of Science-article

C2 - 32518235

VL - 11

SP - 2917

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

ER -

ID: 3397096